王锋鹏

简介:王锋鹏,四川大学教授、博士生导师,九三学社社员,成都市药学会理事长、中国药学会中药和天然药物专委会委员,主要从事抗癌药物及其多药耐药的化学和机理研究。
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王锋鹏的个人经历

人物履历

1965-1969四川医学院药学系本科

1969-1981四川医学院药学系教师

1981-1984中国医学科学院药物研究所获得理科(药物化学专业)硕士学位(导师: 方起程研究员)

1984-1987中国医学科学院药物研究所获得理科博士学位(导师: 梁晓天院士)。1985-1987美国佐治亚大学天然产物研究所作博士后研究(导师: S. W. Pelletier教授)。

1987-1992 华西医科大学药学院副教授

王锋鹏

1992-2000 华西医科大学药学院教授,博士生导师,副院长,院长。

2000-至今四川大学华西药学院教授,博士生导师。

社会职务

成都市药学会理事长、中国药学会中药和天然药物专委会委员, 《亚洲天然产物研究杂志》(英文)、《中国药学》(英文)、《天然产物研究与开发》和《云南植物研究》编委

研究方向

1.抗癌药物及其多药耐药的化学和机理研究。

2.具抗癌活性的新的天然产物成分(生物碱、萜类、甾体皂苷,尤其是国产乌头属和翠雀属生物碱)的分离、结构阐明及其合成;

3.天然产物化学在我国西南省区生物多样性保护、经济发展和药物开发方面的研究

研究成果

1. 紫杉醇及其类似物的合成研究 (国家自然科学基金,2001.1~2003.12)

2. 逆转抗癌药多药耐药性药物构效及其作用机制的研究 (国家自然科学基金, 2002.1~2004.12)

3. 中药现代化研究与产业化开发:四川中药现代化科技产业基地建设—一类中药新药化疗药物增敏剂W198的研制 (国家科技部重点攻关项目 2001.1~2003.12)

4. 国产乌头属植物生物碱的化学研究(Ⅱ) (博士点基金,2002.01~2004.12)

5. 一类新药抗癌药增敏剂W198的研制 (与成都康弘制药公司合作项目,横向,2001~2003)

6. 紫杉醇及其类似物的合成研究(III) (国家自然科学基金,2005.1~2007.12)

代表论著

1.Feng-peng Wang and Xiao-tian Liang, Interconverson of C20-hetidine-type and atisine-type diterpenoid alkaloids, Cleavage and regeneration of C(20)-C(14) bond, Tetrahedron, 42, 265-271(1986).

2.Feng-peng Wang and S. W. Pelletier, Diterpenoid alkaloids from Aconitum crassicaule W. T. Wang, J. Nat. Prod, 50, 55-62(1987).

3.Hai-yan Pu, Feng-peng Wang and Chun-tao Che, Norditerpenoid Alkaloids from the Roots of Delphinium potaninii, Phytochemistry, 43, 287-290(1996).

4.Feng-peng Wang, Jian-zhong Wang and Rong Zhang, Chemistry of denudatine V. Rearrangement Reactions of denudatine, Heterocycles, 45, 659-672(1997).

5.Feng-peng Wang, Chong-sheng Peng, and Kai-bei Yu, Racemulosine, a novel skeletal C20-diterpenoid alkaloid from Aconitum racemulosum Franch var. pengzhouense, Tetrahedron, 56, 7443-7446(2000).

6.Feng-peng Wang, Jin-song Yang, Lin Yu, Bo-gang Li, New access to 7, 17-seco norditerpenoid alkaloids via reduction of the corresponding 8-chlro derivatives, Chem. Pharm. Bull, 48(12), 1912-1916(2000).

7.Feng-peng Wang, Qiao-hong Chen, Bo-gang Li, Novel Synthesis of 12,13-seco norditerpnenoid alkaloids via semipinacol rearrangement and reaction with Br2-HOAc, Tetrahedron, 57(22), 4705-4712(2001).

8.Liang Xu, Qiao-hong Chen, Feng-peng Wang, A novel skeletal rearrangement of the A ring of the immonium salt derived form norditerpenoid alkaloid yunaconitine, Tetrahedron, 58(21), 4267- 4271(2002).

9.Qiao-hong Chen, Feng-peng Wang, Further studies on synthesis of the 12,13-seco norditerpenoid alkaloids, Chem. Pharm. Bull, 50, 1310-1317 (2002).

10.Qiao-hong Chen, Liang Xu, Feng-peng Wang, A novel conversion of norditerpenoid alkaloids into aconane-type diterpenes, Tetrahedron, 58, 9431-9444(2002).

11.Qiao-hong Chen, Liang Xu, Feng-peng Wang, A new access to the cleavage of the N,19-bond of norditerpenoid alkaloids and their derivatives by formation of oxaziridines, Heterocycles, 57(12), 2357- 2363(2002).

12.Feng-peng Wang and Xiao-tian Liang: Chemistry of Diterpenoid Alkaloids, in "The Alkaloids: Chemistry and Pharmacology " (G. A. Cordell ed.), Academy Press, vol. 42, p.151-247(1992).

13.Feng-peng Wang and Xiao-tian Liang, C20-Diterpenoid Alkaloids, in “The Alkaloids: Chemistry and Pharmacology” (G. A. Cordell, ed.), Vol. 59, pp. 1~280, Elsevier Press, (2002).

14.Jing Jin, Feng-Peng Wang, Huai-Ling Wei Geng-Tao Liu, Reversal of multidrug resistance of cancer through inhibition of P-glycoprotein by 5-bromotetrandrine, Cancer Chemother. Pharmacol, 55, 179-188 (2005).

15.Feng Gao and Feng-Peng Wang, Structural revision of hemsleyadine and new alkaloids hemsleyanines A, B from Aconitum hemsleyanium var. circinacum, Heterocycles, 65(2),365-370 (2005).

16.Feng-Peng Wang and Liang Xu, To seek an approach toward the chemical conversion of C19-diterpenoid alkaloids to taxoids, Tetrahedron, 61, 2149-2167 (2005).

17.Xiang-Li Shen and Feng-Peng Wang, mCPBA Oxidation of acetyllycoctonine and its new products, Chem. Pharm. Bull, 53(3), 267-270(2005).

18.Bowen Ke, Yong Qin, Qinfei He, Zhiyan Huang and Fengpeng Wang, Preparation of bisindolylalkanes from N-tert-butanesulfinyl aldimines, Tetrahedron Lett. 46(10), 1751-1753 (2005).

19.Liang Xu and Feng-Peng Wang, Exhaustive degradation of the ring D of 3,20-epoxy ent-kaurane-type diterpene maoecrystal A, Tetrahedron, 61, 4467-4474 (2005).

更新日期:2024-05-05