1982.09-1986.03 黑龙江大学计算机科学与工程系获理学学士学位

1986.09-1989.03 哈尔滨工业大学计算机科学与技术系获硕士学位

1989.03-1991.11 哈工大计算机科学与技术系 助教

1991.12-1996.06 哈工大计算机科学与技术系 讲师

1996.07-2001.04 哈工大计算机科学与技术系 副教授

2001.05-至今 哈工大计算机科学与技术学院 教授

2005.06-至今 哈工大计算机科学与技术学院 博士生导师

2001.08-2001.12 哈工大计算机科学与技术学院 院长助理

2001.12-2010.11 哈工大计算机科学与技术学院 副院长

2008.01-2009.01 美国印第安那大学/普渡大学 访问教授

2011.01-2014.09 哈工大计算机科学与技术学院 院长

2014.09-至今 哈工大计算机科学与技术学院院长、软件学院院长

哈尔滨工业大学计算机科学与技术学院院长、软件学院院长

黑龙江省生物医学信息技术与系统工程研究中心主任

黑龙江省生物信息技术重点实验室主任

哈工大-韩国SK生物医学信息技术联合实验室主任

黑龙江省政协常委

国家“863”计划重大项目“生物大数据开发与利用关键技术研究”首席科学家

国家“863”计划生物信息技术专题“十三五” 规划专家组组长

国家“863”计划生物信息技术主题专家组专家（2001-2011）

黑龙江省计算机学会副理事长

中国计算机学会理事

《 生物信息学》期刊编委

2014年IEEE生物信息学和生物医学国际会议共同主席（2014 IEEE International Conference on Bioinformatics and Biomedicine Conference Co-Chair and Program Co-Chair）

机器学习， 知识工程， 数据挖掘， 生物信息学， 医学信息处理，生物大数据分析等。

王亚东教授 在国内率先开展生物信息学的研究，作为资深专家有力地推动了我国在生物信息学方面的研究工作。

他主持完成国家科技重大工程、国家863计划项目、 国家自然科学基金、国际合作项目等20余项，其中国家重大专项项目1项，国家科技支撑计划重点项目1项，国家863计划项目10余项，国家自然科学基金项目5项，国际合作项目5项。王亚东教授荣获国家科技进步二等奖1项、省科技进步二等奖1项、省自然科学二等奖2项；在《 Nucleic Acids Research》(SCI,IF 8.278)、《 Bioinformatics》(SCI,IF 5.323)、《Human Mutation》(SCI,IF 5.213)、《BMC Genomics》(SCI,IF 4.40)、《BMC Bioinformatics》(SCI,IF 3.02)等国际著名期刊发表论文150余篇，单篇最高他引314次，入选2009年“中国百篇最具影响力国际学术论文”。王亚东教授代表性学术论文的影响因子总和超过150。

生物大数据表述索引、搜索与存储访问技术，国家863计划重大项目，2015.01-2017.12

生物数字资源集成和信息服务关键技术研发, 国家863计划项目，2014.01-2016.12

医疗物联网关键技术研究与设备开发及验证, 国家科技重大专项，2013.01-2015.12

医疗信息集成融合技术与系统开发, 国家863计划项目，2011.01-2015.12

个人健康信息获取与管理技术研究，国家863计划项目，2012.01-2015.12

转化生物信息学重大产品研制，国家863计划项目，2012.01-2014.12

哈尔滨工业大学-爱思开医疗信息技术联合研究实验室，国际合作项目，2011.01-2014.12

基于新一代测序数据的基因组拼接组装算法研究 ，国家自然科学基金，2011.01-2015.12

基于个体基因组单核苷酸突变的等位基因转录调控模型研究，国家自然科学基金，2014.01-2017.12

基于多参考基因组的高通量测序片段映射方法研究，国家自然科学基金，2014.01-2016.12

基于生物数据融合的致病microRNA识别方法研究，国家自然科学基金，2012.01-2014.12

人类复杂疾病相关的非编码区调控性单核苷酸变异预测研究，国家自然科学基金，2014.01-2016.12

项目“农业专家系统及其开发工具研究”获第一届黑龙江省高校科学技术一等奖 (2002)

项目“复杂疾病基因作图的模式识别方法研究”获黑龙江省高校科学技术一等奖和黑龙江省自然科学技术二等奖（2005）

项目“J-220-2-15 农业专家系统研究及应用”获国家科技进步奖 (通用项目)二等奖 (2006)

项目“基于机器学习的色彩自动匹配技术研究”获黑龙江省自然科学技术二等奖 （2006）

论文《miR2Disease: a manually curated database for microRNA deregulation in human disease》获中国百篇最具影响国际学术论文奖 (2010) 和第十二届黑龙江省自然科学技术学术成果奖一等奖 (2011)

个人基因组浏览器PGB是全球首个针对个人基因组而定制的浏览器，相关论文《The Personal Genome Browser: Visualizing Functions of Genetic Variants》发表在Nucleic Acids Research(2014年IF：8.278)。审稿人高度评价研究的重要意义“You do a lot of great works to the world”，标志着我国在这一全新的研究领域完成了领航任务。

miR2Disease

　　miR2Disease, a manually curated database, aims at providing a comprehensive resource of miRNA deregulation in various human diseases.

Personal Genome Browser

　　Personal Genome Browser, a genome browser for visualizing individual genetic variants and their functions, with support of diverse genomic annotations and knowledge bases.

SIDD

　　SIDD aims to establish semantic associations among disease-related databases and integrate them to provide disease global view at biological levels.

PRISM

　　PRISM is a software for split read (reads which span across a structrual variant — SV ) mapping and SV calling from the mapping result. PRISM is able to detect small insertions and abitrary size deletions, inversions and tandom duplications with the direction of discordant read pairs. PRISM_CTX is a tool for detecting inter-chromosome trans-location events.

DNMFilter

ESclassifier

　　ESclassifier is a supervised machine learning-based approach for exon skipping event detection from RNA-Seq data

lncRNA2Target

　　lncRNA2Target, a manually curated database for differentially expressed genes after lncRNA knockdown or over expression.

LncRNA2Function

　　LncRNA2Function, an ontology-driven user-friendly web interface named lncRNA2Function, which enables researchers to browse the lncRNAs associated with a specific functional term, the functional terms associated with a specific lncRNA, or to assign functional terms to a set of human lncRNA genes, such as a cluster of co-expressed lncRNAs.

TF2Lncrna

　　TF2Lncrna, a web interface contains two panels on the left and right hand side, which allow users to input a set of lncRNAs for finding their common TFs or for browsing and retrieving TF-lncRNA regulatory relationships for a specific TF or lncRNA in a specific cell line of interest.

生物信息学导论（本科生课程）

知识工程（硕士研究生课程）

（*代表通讯作者）

Qing Zhan, Yongtao Ye, Tak-Wah Lam, S.M. Yiu, Hingfung Ting andYadong Wang*. Improving multiple sequence alignment by using better guide trees. BMC Bioinformatics. 2014. (Accepted)


Jiajie Peng^, Hongxiang Li^, Qinghua Jiang,Yadong Wang*and Jin Chen*. An Integrative Approach for Measuring Semantic Similarities using Gene Ontology. BMC Systems Biology. 2014. (Accepted)

Jiang QH^, Ma R^, Wang JX, Wu XL, Jin SL, Peng JJ, Tan RJ, Zhang TJ, Li Y,Wang Yadong*. LncRNA2Function: a comprehensive resource for functional investigation of human lncRNAs based on RNA-seq data. BMC genomics. 2014. (Accepted)

Yang Bai, Shufan Ji,Yadong Wang*. ESclassifier: a random forest classifier for detection of exon skipping events from RNA-Seq data. IEEE International Conference on Bioinformatics and Biomedicine (Accepted). 2014.

Cheng L, Li J, Ju P, Peng J,Wang Yadong*. SemFunSim: A New Method for Measuring Disease Similarity by Integrating Semantic and Gene Functional Association. PLoS ONE. 2014. 9(6): e99415. doi:10.1371/journal.pone.0099415

Liran Juan, Mingxiang Teng, Tianyi Zang, Yafeng Hao, Chengwu Yan, Zhenxing Wang, Yongzhuang Liu, Jie Li, Tianjiao Zhang andYadong Wang*. The Personal Genome Browser: Visualizing Functions of Genetic Variants. Nucleic Acids Research. (Accepted)

Liu Y, Li B, Tan R, Zhu X,Wang Yadong*. A gradient boosting approach for filtering de novo mutations in parent-offspring trios. Bioinformatics. 2014 Mar 10. [Epub ahead of print]

Tan R,Wang Yadong*, Kleinstein SE, Liu Y, Zhu X, Guo H, Jiang Q, Allen AS, Zhu M. An Evaluation of Copy Number Variation Detection Tools from Whole-Exome Sequencing Data. Hum Mutat. 2014 Mar 5. doi: 10.1002/humu.22537. [Epub ahead of print]

Jin Shuilin, Tan Renjie, Jiang Qinghua, Xu Li, Peng Jiajie, Wang Yong,Wang Yadong*. A Generalized Topological Entropy for Analyzing the Complexity of DNA Sequences. PLOS ONE. FEB 12 2014;9(2):e88519. 10.1371/journal.pone.0088519

Peng Jiajie,Wang Yadong*, Chen Jin. Towards integrative gene functional similarity measurement. BMC BIOINFORMATICS. JAN 24 2014;15(Suppl 2):UNSP S5. 10.1186/1471-2105-15-S2-S5

Zhang Denan, Wang Guohua,Wang Yadong*. Transcriptional regulation prediction of antiestrogen resistance in breast cancer based on RNA polymerase II binding data. BMC BIOINFORMATICS. JAN 24 2014;15(Suppl 2):S10. 10.1186/1471-2105-15-S2-S10

Jiang Qinghua, Wang Jixuan,Wang Yadong*, Ma Rui, Wu Xiaoliang, Li Yu. TF2LncRNA: Identifying Common Transcription Factors for a List of lncRNA Genes from ChIP-Seq Data. BIOMED RESEARCH INTERNATIONAL. 2014:317642. 10.1155/2014/317642

Zhang Shaojun, Wang Fang, Wang Hongzhi, Zhang Fan, Xu Bin, Li Xia,Wang Yadong*. Genome-wide identification of allele-specific effects on gene expression for single and multiple individuals. GENE. JAN 1 2014;533(1). 366-73. 10.1016/j.gene.2013.09.029

Cheng Liang, Wang Guohua, Li Jie, Zhang Tianjiao, Xu Peigang,Wang Yadong*. SIDD: A Semantically Integrated Database towards a Global View of Human Disease. PLOS ONE. OCT 11 2013;8(10):e75504. 10.1371/journal.pone.0075504

Zhu Shijia, Wang Guohua, Liu Bo,Wang Yadong*. Modeling Exon Expression Using Histone Modifications. PLOS ONE. JUL 2013;8(6):e67448. 10.1371/journal.pone.0067448

Juan Liran, Wang Guohua, Radovich Milan, Schneider Bryan P., Clare Susan E.,Wang Yadong*, Liu Yunlong. Potential roles of microRNAs in regulating long intergenic noncoding RNAs. BMC MEDICAL GENOMICS. JAN 23 2013;6(Suppl 1):S7. 10.1186/1755-8794-6-S1-S7

Wang Guohua, Qi Ke, Zhao Yuming, Li Yu, Juan Liran, Teng Mingxiang, Li Lang, Liu Yunlong,Wang Yadong*. Identification of regulatory regions of bidirectional genes in cervical cancer. BMC MEDICAL GENOMICS. JAN 23 2013;6(Suppl 1):S5. 10.1186/1755-8794-6-S1-S5

Peng Jiajie, Chen Jin,Wang Yadong*. Identifying cross-category relations in gene ontology and constructing genome-specific term association networks. BMC BIOINFORMATICS. JAN 21 2013;14(Suppl 2):S15. 10.1186/1471-2105-14-S2-S15

Jiang Yue,Wang Yadong*, Brudno Michael. PRISM: Pair-read informed split-read mapping for base-pair level detection of insertion, deletion and structural variants. BIOINFORMATICS. OCT 15 2012;28(20). 2576-83. 10.1093/bioinformatics/bts484

Teng Mingxiang, Ichikawa Shoji, Padgett Leah R.,Wang Yadong*, Mort Matthew, Cooper David N., Koller Daniel L., Foroud Tatiana, Edenberg Howard J., Econs Michael J., Liu Yunlong. regSNPs: a strategy for prioritizing regulatory single nucleotide substitutions. BIOINFORMATICS. JUL 15 2012;28(14). 1879-86. 10.1093/bioinformatics/bts275

Teng Mingxiang, Balch Curt, Liu Yunlong, Li Meng, Huang Tim H. M.,Wang Yadong*, Nephew Kenneth P., Li Lang. The Influence of cis-Regulatory Elements on DNA Methylation Fidelity. PLOS ONE. MAR 6 2012;7(3):e32928. 10.1371/journal.pone.0032928

Hu Yang, Liu Yunlong, Jung Jeesun, Dunker A. Keith,Wang Yadong*. Changes in predicted protein disorder tendency may contribute to disease risk. BMC GENOMICS. DEC 23 2011;12(Suppl 5):S2. 10.1186/1471-2164-12-S5-S2

Zhu Shijia, Jiang Qinghua, Wang Guohua, Liu Bo, Teng Mingxiang,Wang Yadong*. Chromatin structure characteristics of pre-miRNA genomic sequences. BMC GENOMICS. JUN 25 2011;12:329. 10.1186/1471-2164-12-329

Shen Changyu, Huang Yiwen, Liu Yunlong, Wang Guohua, Zhao Yuming, Wang Zhiping, Teng Mingxiang,Wang Yadong, Flockhart David A., Skaar Todd C., Yan Pearlly, Nephew Kenneth P., Huang Tim H. M., Li Lang. A modulated empirical Bayes model for identifying topological and temporal estrogen receptor alpha regulatory networks in breast cancer. BMC SYSTEMS BIOLOGY. MAY 9 2011;5:67. 10.1186/1752-0509-5-67

Wang Guohua,Wang Yadong*, Shen Changyu, Huang Yiwen, Huang Kun, Huang Tim H. M., Nephew Kenneth P., Li Lang, Liu Yunlong. RNA Polymerase II Binding Patterns Reveal Genomic Regions Involved in MicroRNA Gene Regulation. PLOS ONE. NOV 2 2010;5(11):e13798. 10.1371/journal.pone.0013798

Wang Guohua,Wang Yadong*, Teng Mingxiang, Zhang Denan, Li Lang, Liu Yunlong. Signal Transducers and Activators of Transcription-1 (STAT1) Regulates microRNA Transcription in Interferon gamma-Stimulated HeLa Cells. PLOS ONE. JUL 26 2010;5(7):e11794. 10.1371/journal.pone.0011794

Jiang Qinghua, Hao Yangyang, Wang Guohua, Juan Liran, Zhang Tianjiao, Teng Mingxiang, Liu Yunlong,Wang Yadong*. Prioritization of disease microRNAs through a human phenome-microRNAome network. BMC SYSTEMS BIOLOGY. MAY 28 2010;4(Suppl 1):S2. 10.1186/1752-0509-4-S1-S2

Wang Yadong, Wang Guohua, Yang Bo, Tao Haijun, Yang Jack Y., Deng Youping, Liu Yunlong. Reconstruct gene regulatory network using slice pattern model. BMC GENOMICS. 2009;10(Suppl 1):S2. 10.1186/1471-2164-10-S1-S2

Jiang Qinghua,Wang Yadong*, Hao Yangyang, Juan Liran, Teng Mingxiang, Zhang Xinjun, Li Meimei, Wang Guohua, Liu Yunlong. miR2Disease: a manually curated database for microRNA deregulation in human disease. NUCLEIC ACIDS RESEARCH. JAN 2009;37. D98-104. 10.1093/nar/gkn714

Jiang Wei, Li Xia, Rao Shaoqi, Wang Lihong, Du Lei, Li Chuanxing, Wu Chao, Wang Hongzhi,Wang Yadong, Yang Baofeng. Constructing disease-specific gene networks using pair-wise relevance metric: Application to colon cancer identifies interleukin 8, desmin and enolase 1 as the central elements. BMC SYSTEMS BIOLOGY. AUG 10 2008;2:72. 10.1186/1752-0509-2-72

Dong Qiwen, Wang Xiaolong, Lin Lei,Wang Yadong. Analysis and prediction of protein local structure based on structure alphabets. PROTEINS-STRUCTURE FUNCTION AND BIOINFORMATICS. JUN 2008;72(1). 163-72. 10.1002/prot.21904

Wang Guohua,Wang Yadong, Feng Weixing, Wang Xin, Yang Jack Y., Zhao Yuming, Wang Yue, Liu Yunlong. Transcription factor and microRNA regulation in androgen-dependent and -independent prostate cancer cells. BMC GENOMICS. 2008;9(Suppl 2):S22. 10.1186/1471-2164-9-S2-S22

Wang Guohua, Wang Xin,Wang Yadong, Yang Jack Y., Li Lang, Nephew Kenneth P., Edenberg Howard J., Zhou Feng C., Liu Yunlong. Identification of transcription factor and microRNA binding sites in responsible to fetal alcohol syndrome. BMC GENOMICS. 2008;9(Suppl 1):S19. 10.1186/1471-2164-9-S1-S19

Zhang Wei, Li Li, Li Xia, Jiang Wei, Huo Jianmin,Wang Yadong, Lin Meihua, Rao Shaoqi. Unravelling the hidden heterogeneities of diffuse large B-cell lymphoma based on coupled two-way clustering. BMC GENOMICS. SEP 22 2007;8:332. 10.1186/1471-2164-8-332

Li X, Rao SQ,Wang YD, Gong BS. Gene mining: a novel and powerful ensemble decision approach to hunting for disease genes using microarray expression profiling. NUCLEIC ACIDS RESEARCH. MAY 2004;32(9). 2685-94. 10.1093/nar/gkh563